Sabine Montaut

Recherche

Notre groupe s’intéresse à la chimie des produits naturels. Nos intérêts de recherche concernent principalement l’isolement de métabolites secondaires issus de plantes supérieures, ainsi que leurs déterminations structurales en utilisant les méthodes spectroscopiques modernes. Nous nous concentrons en particulier sur les nouveaux produits naturels susceptibles d’avoir des activités biologiques.

Profil de recherche

Dr Gina Rosalinda De Nicola et Dr Sabine Montaut sont les rédactrices invitées du numéro spécial "Extraction, Isolation, and Identification of Bioactive Compounds from Plants" dans la revue Molecules.

Notre laboratoire est inclusif, attaché à l’équité en matière d’emploi, accueille favorablement la diversité & encourage les candidatures de toutes les personnes qualifiées, y compris les femmes, les membres des minorités visibles, les personnes autochtones, les personnes handicapées & les personnes de toutes orientations & identités/expressions de genre. 

Prix

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• 2022 Augmentation au mérite (Université Laurentienne)
• 2013 Prix de recherche de l' ACFAS-Sudbury
• 2012 Prix de l'ambassade de France au Canada pour la mobilité de chercheurs canadiens
• 2006 Fonds des leaders de la Fondation Canadienne pour l'Innovation
• 2006 Prix de voyage de la Société française de chimie 

Enseignement

BMOL6106EL Cell Regulation (participation)

BMOL6207EL Structure and Function of Biomolecules (participation)

CHMI1032EL12 Essential Concepts of Organic Chemistry

CHMI1041EL Chemical Concepts

CHMI1202EL Organic Chemistry and Biochemistry for Health Sciences

CHMI1202FL Chimie organique et biochimie en sciences de la santé

CHMI2031EL10 Natural Products: Organic and Biochemical Features

CHMI2426EL Organic Chemistry 1

CHMI2426FL Chimie organique 1

CHMI2426T Organic Chemistry 1 tutorials/Travaux dirigés de chimie organique 1

CHMI2427EL Organic Chemistry 2

CHMI2427FL Chimie organique 2

CHMI3257EL Principles of Pharmacology

CHMI3416EL Spectroscopic Techniques in Organic Chemistry*

CHMI3416FL Méthodes d'analyses spectroscopiques en chimie organique*

CHMI3427EL Introduction to Medicinal Chemistry

CHMI3436FL Laboratoire avancé de pharmacognosie - chimie des produits naturels 1

CHMI3437FL Laboratoire avancé de pharmacognosie - chimie des produits naturels 2

CHMI3446EL Chemical Pharmacognosy*

CHMI3457FL Introduction à la chimie des produits naturels​

CHMI4497EL Natural Products Chemistry

CHMI5000EL Thesis (M.Sc. in Chemical Sciences, coordination)*

CHMI5000FL Thèse (M.Sc. in Chemical Sciences, coordination)*

CHMI5005EL Critical Review Essay (M.Sc. in Chemical Sciences, coordination)*

CHMI5606FL Research Seminar in Chemistry (M.Sc. in Chemical Sciences, coordination)*

* Charge d'enseignement 2024-2025

Publications

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Chapitres de livres académiques

• Blažević I., Montaut S., Burčul F., Rollin P. 2017. Glucosinolates: Novel Sources and Biological Potential, In Reference Series in Phytochemistry. Glucosinolates. 1st edition. Ed. K. G. Ramawat and J.-M. Mérillon. Springer International Publishing, Cham, Switzerland. pp. 3-60. Print + eReference ISBN 978-3-319-25749-5. Print ISBN 978-3-319-25461-6. eReference ISBN 978-3-319-25462-3. DOI 10-1007/978-3-319-26479-0. 
• Montaut S., Rollin P. 2016. Chapter 2 Glucosinolates and their distribution. In Broccoli: Cultivation, Nutritional Properties and Effects on Health.  Ed. B. Juurlink.  Nova Publishers Inc. pp. 9-31. ISBN: 978-1-63484-313-3. 

 

Articles (dans des revues à comité de lecture)

2024

• De Nicola G.R., Montaut S., Leclair K., Garrioux J., Guillot X., Rollin P. 2024. Cultivated winter-type Lunaria annua L. seed: Deciphering the glucosinolate profile integrating HPLC, LC-MS and GC-MS analyses, and determination of fatty acid composition. Molecules, 29, 3803.
• Harvey F., Aromokunola B., Montaut S., Yang G. 2024. The antioxidant properties of glucosinolates in cardiac cells are independent of H2S signaling. International Journal of Molecular Sciences 25(2), 696.

2022

• ​Agerbirk N., Pattison D. I., Mandáková T., Lysak M. A., Montaut S., Stærk D. 2022. Ancient biosyntheses in an oil crop: Glucosinolate profiles in Limnanthes alba and its relatives (Limnanthaceae, Brassicales). Journal of Agricultural and Food Chemistry 70, 1134-1147.

2021

• Đulović A., Burčul F., Čikeš Čulić V., Ruščić M., Brzović P., Montaut S., Rollin P., Blažević I. 2021. Lepidium graminifolium L.: Glucosinolate profile and antiproliferative potential of volatile isolates. Molecules 26, 5183.

• Montaut S., Read S., Blažević I., Nuzillard J.-M., Harakat D., Rollin P. 2021. Glucosinolates of Lepidium graminifolium L. (Brassicaceae) from Croatia. Natural Product Research 35, 494-498.​

2020

• Montaut S., Raharivelomanana P., Butaud J.-F., Lehartel T., Rollin P. 2020. Glucosinolates of the only three Brassicales indigenous to French Polynesia. Natural Product Research 34, 2847-2851.

• Lewicky J.D., Fraleigh N.L., Boraman A., Martel A.L., Nguyen T.M.-D., Schiller P.W., Shiao T.C., Roy R., Montaut S., Le H.-T. 2020. Mannosylated glycoliposomes for the delivery of a peptide kappa opioid receptor antagonist to brain. European Journal of Pharmaceutics and Biopharmaceutics, 154, 290-296.

• Blažević I., Đulović A., Burčul F., Popović M., Montaut S., Bilušić T., Vrca I., Markić J., Ljubenkov I., Ruščić M., Rollin P. 2020. Stability and bioaccessibility during ex vivo digestion of glucoraphenin and glucoraphasatin from Matthiola incana (L.) R.Br. Journal of Food Composition and Analysis, 90, 103483. ​

• Pagnotta E., Montaut S., Matteo R., Rollin P., Nuzillard J.-M., Lazzeri L., Bagatta M. 2020. Glucosinolates in Reseda lutea L.: Distribution in plant tissues during flowering time. Biochemical Systematics and Ecology, 90, 104043. 

• ​Montaut S., Read S., Marquis F., Bizard L., Rollin P. 2020. Glucosinolates in wild and cultivated Brassica montana Pourret (Brassicaceae) from southern France. Natural Product Research, 34(8), 1163-1166. 

• Le H.-T., Fraleigh N. L., Lewicky J.D., Boudreau J., Dolinar P., Bhardwaj N., Diaz-Mitoma F., Montaut S., Fallahi S., Martel A.L. 2020. Enhancing the immune response of nicotine vaccine with synthetic small “non-natural” peptides. Molecules, 25(6), 1290. 

• Montaut S., Read S., Blažević I., Nuzillard J.-M., Harakat D., Roje M., Rollin P. 2020. Investigation of the glucosinolates of Hesperis matronalis L. and Hesperis laciniata All.: Unveiling 4'-O-b-D-apiofuranosylglucomatronalin. Carbohydrate Research, 488, 107898. 

• Blažević I., Montaut S., Burčul F., Olsen C.E., Burow M., Rollin P., Agerbirk N. 2020. Glucosinolate structural diversity, identification, chemical synthesis and metabolism by plants. Phytochemistry, 169, 112100. 

2019

• Lafite P., Marroun S., Coadou G., Montaut S., Marquès S., Schuler M., Rollin P., Tatibouët A., Daniellou R., Oulyadi H. 2019. S-Glycosyltransferase UGT74B1 can glycosylate both S- and O- acceptors: mechanistic insights through substrate specificity. Molecular Catalysis, 479, 110631. 

• ​Buckner A.L., Buckner C.A., Montaut S., Lafrenie R.M. 2019. Treatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon, 5, e02251.​ 

• Nyegue M.A., Montaut S., De Nicola G.R., Rollin P., Menut C. 2019. Applying the hydrodistillation process to Pentadiplandra brazzeana (Baill.) root: a chemical assessment. Natural Product Research, 33, 1383-1386. 

• Blažević I., Đulović A., Maravić A., Čikeš-Čulić V., Montaut S., Rollin P. 2019. Antimicrobial and cytotoxic activities of Lepidium latifolium L. hydrodistillate, extract and its major sulfur volatile allyl isothiocyanate. Chemistry and Biodiversity, 16, e1800661. 

2018

• Martel A.L., Montaut S., Ulíbarri G., Spiers G.A. 2018. Conversion of Symphytum officinale L. and Panicum virgatum L. plant extracts to 5-hydroxymethylfurfural catalysed by metal chlorides in ionic liquids. Canadian Journal of Chemistry, 96, 815-820. 

• Mavratzotis M., Cassel S., Montaut S., Rollin P. 2018. w-Methylsulfanylalkyl glucosinolates: a general synthetic pathway. Molecules, 23, 786. 

• Montaut S., Montagut-Romans A., Chiari L., Benson H.J. 2018. Glucosinolates in Draba borealis DC. (Brassicaceae) in a taxonomic perspective. Biochemical Systematics and Ecology, 78, 31-34.

2017

• Montaut S., Benson H.J., Kay M., Guido B.S., Mahboob S.S., Chénier J., Gasparetto J.-L., Joly H.A. 2017. Probing the free-radical scavenging activity of the extract, the major glucosinolate and isothiocyanate of Eruca sativa Mill. and Lepidium densiflorum Schrad. seeds. Journal of Food Composition and Analysis, 61, 52-58.

• Montaut S., Guido B.S., Grison C., Rollin P. 2017. Identification of glucosinolates in seeds of three Brassicaceae species known to hyperaccumulate heavy metals. Chemistry and Biodiversity, 14, e1600311. 

• Montaut S., De Nicola G.R., Agnaniet H., Issembe Y., Rollin P., Menut C. 2017. Probing for the presence of glucosinolates in three Drypetes spp. (Drypetes euryodes (Hiern) Hutch., Drypetes gossweileri S. Moore, Drypetes laciniata Hutch.) and two Rinorea spp. (Rinorea subintegrifolia O. Ktze and Rinorea woermanniana (Büttner) Engl.) from Gabon. Natural Product Research, 31, 308-313. 

• Montaut S., Blažević I., Ruščić M., Rollin P. 2017. LC-MS profiling of glucosinolates in the seeds of Brassica elongata Ehrh., and of the two stenoendemic B. botteri Vis and B. cazzae Ginzb. & Teyber. Natural Product Research, 31, 58-62.

2016

• Marroun S., Montaut S., Marquès S., Lafite P., Coadou G., Rollin P., Jousset G., Schuler M., Tatibouët A., Oulyadi H., Daniellou R. 2016. UGT74B1 from Arabidopsis thaliana as a versatile biocatalyst for the synthesis of desulfoglycosinolates. Organic and Biomolecular Chemistry, 14, 6252-6261.

• Liu M., Wu L., Montaut S., Yang G. 2016. Hydrogen sulfide signalling axis as a target for prostate cancer therapeutics. Prostate Cancer, 2016, Article ID 8108549, 9 pages. 

2015

• Blažević I., De Nicola G. R., Montaut S., Rollin P., Ruščić M. 2015. Glucosinolate profile of Fibigia triquetra (DC.) Boiss. Ex Prantl., Croatian stenoendemic plant of the Brassicaceae family. Croatica Chemica Acta, 88, 307-314.

• Giacoppo S., Galuppo M., Montaut S., Iori R., Rollin P., Bramanti P., Mazzon E. 2015. An overview on neuroprotective effects of isothiocyanates for the treatment of neurogenerative diseases. Fitoterapia, 106, 12-21. 

• Montaut S., Zhang W.-D., Nuzillard J.-M., De Nicola G.R., Rollin P. 2015. Glucosinolate diversity in Bretschneidera sinensis of Chinese origin. Journal of Natural Products, 78, 2001-2006. 

• Blažević I., Montaut S., De Nicola G. R., Rollin P. 2015. Long-chain glucosinolates from Arabis turrita L.: Enzymatic and non-enzymatic degradations. Natural Products Communications, 10(6), 1043-1046. 

2013

• Blažević I., De Nicola G. R., Montaut S., Rollin P. 2013. Glucosinolates in two endemic plants of Aurinia genus and their chemotaxonomic significance. Natural Product Communications, 8(10), 1463-1466.

• Montaut S., Bleeker R.S. 2013. Review on Cardamine diphylla (Michx.) A. Wood (Brassicaceae): ethnobotany and glucosinolate chemistry. Journal of Ethnopharmacology, 149, 401-408. 

• De Nicola G.R., Montaut S., Rollin P., Nyegue M., Menut C., Iori R., Tatibouët A. 2013. Stability of benzylic-type isothiocyanates in hydrodistillation-mimicking conditions. Journal of Agricultural and Food Chemistry, 61, 137-142. 

2012

• Montaut S., Rollin P., De Nicola G.R., Iori R., Tatibouët A. 2012. Composés bio-actifs des Crucifères : un apport bénéfique dans notre quotidien. Phytothérapie, 10, 342-349. 
• Carion-Bontaz J., Montaut S., Goetz P. 2012. Isatis tinctoria L. Brassicaceae: Le pastel des teinturiers. Phytothérapie, 10, 238-244. 
• Montaut S., Grandbois J., Rossi L.S., Kamal S., Khouri J., Ménard M.G., Joly H.A. 2012. Composition of Dithyrea wislizenii fruit extract and the free-radical scavenging activity of its constituents. Canadian Journal of Chemistry, 90, 652-659. 
• De Nicola G.R., Nyegue M., Montaut S., Iori R., Menut C., Tatibouët A., Rollin P., Ndoyé C., Amvam Zollo P.-H. 2012. Profile and Quantification of Glucosinolates in Pentadiplandra brazzeana Baill. Phytochemistry, 73, 51-56.

2011

• Blažević I., Radonić A., Skočibušić M., De Nicola G.R., Montaut S., Iori R., Rollin P., Mastelić J., Zekić M., Maravić A. 2011. Glucosinolate profiling and antimicrobial activity of Aurinia leucadea (Brassicaceae). Chemistry and Biodiversity, 8(12), 2310-2321. 
• ​De Nicola G.R., Blažević I., Montaut S., Rollin P., Mastelić J., Iori, R., Tatibouët A. 2011. Glucosinolate distribution in aerial parts of Degenia velebitica. Chemistry and Biodiversity, 8(11), 2090-2096.
• Montaut S., Bleeker R.S. 2011. Cardamine sp.: a review on its chemical and biological profiles.  Chemistry and Biodiversity, 8(6), 955-975.

2010

• Pedras M.S.C., Minic Z., Thongbam, P.D., Vangala B., Montaut S. 2010. Indolyl-3-acetaldoxime dehydratase from the phytopathogenic fungus Sclerotinia sclerotiorum: Purification, characterization, and substrate specificity. Phytochemistry, 71, 1952-1962. 
• Zhao Q.-X., Chen Y-.W., Montaut S., Joly H.A., Wang M., Belzile N. 2010. Synthesis, identification and chemical features of high-purity trimethylselenonium iodide. Journal of Sulfur Chemistry, 31, 373-385. 
• Montaut S., Bleeker R.S. 2010. Isolation and structure elucidation of 5´-O-β-D-glucopyranosyldihydroascorbigen from Cardamine diphylla rhizome. Carbohydrate Research, 345, 1968-1970.  
• Montaut S., Barillari J., Iori R., Rollin P. 2010. Glucoraphasatin: chemistry, occurrence, and biological properties. Phytochemistry, 71, 6-12. 
• Montaut S., Bleeker R.S., Jacques C. 2010. Phytochemical Constituents and Biological Activities of Cardamine diphylla rhizome. Canadian Journal of Chemistry, 88, 50-55.

2009

• Montaut S., Grandbois J., Righetti L., Barillari J., Iori R., Rollin P. 2009. Updated Glucosinolate Profile of Dithyrea wislizenii. Journal of Natural Products, 72, 889-893.

2004

• Pedras M.S.C., Hossain M., Sarwar M.G., Montaut S. 2004. Determination of the enantiomeric purity of the phytoalexins spirobrassinins by 1H NMR using chiral solvation. Bioorganic and Medicinal Chemistry Letters, 14, 5459-5471. 
• Pedras M.S.C., Montaut S., Suchý M. 2004. Phytoalexins from the crucifer rutabaga: structures, synthesis, biosynthesis and antifungal activities. Journal of Organic Chemistry, 69, 4471-4476. 
• Pedras M.S.C., Montaut S. 2004. The biosynthesis of crucifer phytoalexins: unprecedented incorporation of a 1-methoxyindolyl precursor. Chemical Communications, 4, 452-453.

2003

• Pedras M.S.C., Montaut S., Zaharia I.L., Gai, Y., Ward, D.E., 2003. Transformation of the host-selective toxin destruxin B by wild crucifers: probing a detoxification pathway. Phytochemistry, 64(5), 957-963. 
• Pedras M.S.C., Montaut S. 2003. Probing crucial metabolic pathways in fungal pathogens of crucifers: biotransformation of indole-3-acetaldoxime, 4-hydroxyphenylacetaldoxime, and their metabolites.  Bioorganic and Medicinal Chemistry, 11, 3115-3120. 

2002

• Pedras M.S.C., Nycholat C.M., Montaut S., Xu Y., Khan A.Q. 2002. Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip.  Phytochemistry, 59(6), 611-625. 
• Fréchard A., Fabre N., Péan C., Montaut S., Fauvel M.T., Rollin P., Fourasté I. 2002. Corrigendum to "Novel indole-type glucosinolates from woad (Isatis tinctoria L.)". Tetrahedron Letters, 43, 1591-1592.

​2001

• Fréchard A., Fabre N., Péan C., Montaut S., Fauvel M.T., Rollin P., Fourasté I. 2001. Novel indole-type glucosinolates from woad (Isatis tinctoria L.). Tetrahedron Letters, 42, 9015-9017. 
• Pedras M.S.C., Montaut S., Xu Y., Khan A.Q., Loukaci A. 2001. Assembling the biosynthetic puzzle of crucifer metabolites: indole-3-acetaldoxime is incorporated efficiently into phytoalexins but glucobrassicin is not. Chemical Communications, 17, 1572-1573.